Obagi Refissa is an emollient and fragrance-free Tretinoin 0.05% Cream designed for your Adult Dry Skin patient type. It is the only prescription retinoid that has it all. This medicine is a vitamin A derivative used to treat wrinkles, brown spots, and surface roughness on the face. Refissa, a new topical formulation of Tretinoin, has been approved by the U.S. Food and Drug Administration (FDA). Refissa is the only 0.05% prescription strength, fragrance-free, emollient-based Tretinoin Cream specifically indicated for dry skin. Refissa has been shown in clinical trials to be less irritating at weeks 2 and 24. It is manufactured by Spear pharmaceuticals and only available to be dispensed within your practice by Obagi. Among topical retinoids, Tretinoin is the "Gold Standard" of treatments, and Refissa, formulated in a moisturizing base, is an ideal option for mature patients with drier photo damaged skin. Sunscreen should be used in conjunction with retinoid products, including Refissa. 71% of women saw improvement in their fine facial wrinkles and 83% saw improvement in irregular pigmentation. Refissa can be used in conjunction with the Nu-Derm and C&E Systems to improve your overall facial appearance.